Potential repurposing of lapatinib and pazopanib as neuroprotective agents in a rat model of Huntington's Disease
Huntington's Disease Overview; Neurodegeneration: A Challenge; Drug Repurposing Strategy; Tyrosine Kinase Inhibitors (TKIs); Lapatinib: A Dual TKI; Pazopanib: Multi-Targeted TKI; 3-NP Induced HD Model; Pathology in Rat Model; Motor Dysfunction in Rats; Cognitive Decline in Rats; Neuroinflammation in HD Rats; Experimental Design: Treatment; Improved Striatal Architecture; Enhanced Neuronal Survival; Reduced Neuroinflammatory Response; NF-κB and TNF-α Modulation; Glutamate/Calpain-2 Axis; Inflammatory Molecule Content; Neurotransmitter Homeostasis; m-Tor/ULK-1/Beclin-1/LC3-II Pathway; Tyrosine Hydroxylase Normalization; Glial Fibrillary Acidic Protein; Pazopanib's Pronounced Effect; Clinical Implications & Future; Discussion: TKI Repurposing
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